Advances in electrochemical detection for probing protein aggregation
نویسندگان
چکیده
Electrochemistry provides an array of methods to investigate protein aggregation and determine biomarkers neurodenenerative diseases. Biosensors detecting monomeric or oligomeric Alzheimer's disease Parkinson's evolved toward femtomolar, multiplexed detection in blood biological fluids for less invasive diagnosis. The biosensors also serve as complementary tools studies investigating putative the assessment patient's cognitive decline. study via direct electrochemical oxidation focused recently on enhanced sensitivity establishing correlations between structure propensity. Departing from classic approaches, nanopore resistive pulse sensing single-particle collision electrochemistry enable studying aggregates solution. Growing applications converge accurate evaluation aggregate populations method adoption beyond proof principle.
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ژورنال
عنوان ژورنال: Current Opinion in Electrochemistry
سال: 2021
ISSN: ['2451-9103', '2451-9111']
DOI: https://doi.org/10.1016/j.coelec.2021.100820